Physical Activity and Type 2 Diabetes: Therapeutic Effects and Mechanisms of Action
Author: John Hawley
Over the past 50 years, there has been a dramatic increase in the prevalence of interrelated metabolic disease states, including obesity, insulin resistance, and type 2 diabetes mellitus. In modern Western nations, the population-based prevalence of insulin resistance is approaching 20%, and type 2 diabetes is now the most common endocrine disorder in adults. No longer a disease reserved for the aging population, type 2 diabetes is also on the rise in adolescents. Approximately 30% of all newly diagnosed cases (between 1982 and 1994 in the United States alone) are among people 10 to 19 years of age.
For those engaged in a struggle against this modern-day epidemic, Physical Activity and Type 2 Diabetes provides cutting-edge research to energize current efforts in diabetes prevention, management, and treatment. The most in-depth and up-to-date book on the topic, Physical Activity and Type 2 Diabetes presents a series of independent but related chapters authored by the foremost researchers of insulin resistance examining topics such as these:
•Physical inactivity as a primary cause for the rising incidence of insulin resistance
•The emergence of an "exercise-deficient" phenotype
•The effects of exercise training on selected aspects of substrate metabolism
•The role of endurance and resistance training programs for the prevention and treatment of insulin resistance
•The identification of new molecular targets and pathways useful for the treatment of insulin resistance and type 2 diabetes.
Physical Activity and Type 2 Diabetes provides a four-part, in-depth examination of the relational nature of diabetes andphysical activity. Part I begins with a description of the scope and extent of the "diabesity" epidemic. The risk factors for diabetes, the underlying causes of the epidemic, and its potential consequences are outlined as well as the role of physical inactivity in the pathogenesis of diabetes and plans for preventive exercise biology.
Part II continues with an examination of some of the major defects of substrate metabolism in individuals with insulin resistance, while in part III the authors discuss the impact of exercise interventions in the prevention, management, and treatment of type 2 diabetes. Part IV presents recent developments in molecular and cellular biology that may provide treatment therapies for the prevention of type 2 diabetes.
Based on extensive research, Physical Activity and Type 2 Diabetes presents a wealth of information to assist the biomedical and research community in creating prescriptive therapeutic tools for type 2 diabetes intervention-and offers hope for the alleviation of the global epidemic of insulin resistance.
Table of Contents:
Pt. I Aetiology of Insulin Resistance and Type 2 Diabetes Prevalence and Consequences of the "Diabesity" Epidemic
Ch. 1 The Increasing Burden of Type 2 Diabetes: Magnitude, Causes, and Implications of the Epidemic Edward W. Gregg Gregg, Edward W. Andrea K. Kriska Kriska, Andrea K. 3
Ch. 2 Waging War on Type 2 Diabetes: Primary Prevention Through Exercise Biology Frank W. Booth Booth, Frank W. Manu V. Chakravarthy Chakravarthy, Manu V. Matthew J. Laye Laye, Matthew J. 15
Pt. II Defects in Metabolism and Insulin Resistance
Ch. 3 Fatty Acid Uptake and Insulin Resistance Arend Bonen Bonen, Arend Adrian Chabowski Chabowski, Adrian Jan F. C. Glatz Glatz, Jan F. C. Joost J. F. P. Luiken Luiken, Joost J. F. P. 25
Ch. 4 Lipid Metabolism and Insulin Signaling Jason R. Berggren Berggren, Jason R. Leslie A. Consitt Consitt, Leslie A. Joseph A. Houmard Houmard, Joseph A. 43
Ch. 5 Metabolic Inflexibility and Insulin Resistance in Skeletal Muscle Bret H. Goodpaster Goodpaster, Bret H. David E. Kelley Kelley, David E. 59
Ch. 6 Nutrient Sensing links Obesity With Diabetes Risk Sarah Crunkhorn Crunkhorn, Sarah Mary Elizabeth Patti Patti, Mary Elizabeth 71
Ch. 7 Inflammation-Induced Insulin Resistance in Obesity: When Immunity Affects Metabolic Control Phlllip James White White, Phlllip James Andre Marette Marette, Andre 83
Pt. III Prevention of Type 2 Diabetes Through Exercise Training
Ch. 8 Transcription Factors Regulating Exercise Adaptation David Kitz Kramer Kramer, David Kitz Anna Krook Krook, Anna 107
Ch. 9 Exercise and Calorie Restriction Use Different Mechanisms to Improve Insulin Sensitivity Gregory D. Cartee Cartee, Gregory D. 119
Ch. 10 Mitochondrial OxidativeCapacity and Insulin Resistance Kevin R. Short Short, Kevin R. 135
Ch. 11 Effects of Acute Exercise and Exercise Training on Insulin Action in Skeletal Muscle Erik A. Richter Richter, Erik A. Jorgen F. P. Wojtaszewski Wojtaszewski, Jorgen F. P. 147
Ch. 12 Resistance Exercise Training and the Management of Diabetes Jorgen F. P. Wojtaszewski Wojtaszewski, Jorgen F. P. Henriette Pilegaard Pilegaard, Henriette Flemming Dela Dela, Flemming 161
Pt. IV Prevention of Type 2 Diabetes Identification of Novel Molecular Targets and Pathways
Ch. 13 AMPK: The Master Switch for Type 2 Diabetes? W. W. Winder Winder, W. W. D. M. Thomson Thomson, D. M. 177
Ch. 14 Protein Kinase C and Insulin Resistance Carsten Schmitz-Peiffer Schmitz-Peiffer, Carsten 187
Ch. 15 Evidence for Prescribing Exercise as a Therapy for Treating Patients With Type 2 Diabetes Sarah J. Lessard Lessard, Sarah J. John A. Hawley Hawley, John A. 203
Index 215
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Prozac and the New Antidepressants: What You Need to Know About Prozac, Zoloft, Paxil, Luvox, Wellbutrin, Effexor, Serzone, Vestra, Celexa, St. John's Wort and Others
Author: William S Appleton
It is estimated that more than eleven million people were taking Prozac, Zoloft, Paxil and the other "new antidepressants" when the original edition of Prosac and the New Antidepressants was published three years ago amid a national debate about their effectiveness, their dangers, and their societal implications. Today the number of people using these drugs is estimated to have doubled , and the number of new drugs to treat depression has increased significantly. The newly-updated Prozac and the New Antidepressants is a practical and user-friendly guide by Harvard Medical School professor William Appleton. It answers all the nuts and bolts questions users of Prozac and the other antidepressants may have, and includes a compendium of all the new drugs approved since the original publication.
What People Are Saying
Leston Havens
From Leston Havens, M.D., professor of psychiatry, Harvard Medical School
Much wise advice, to both patients and their helpers, from a broadly experienced, honest, and modest clinician
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